Exosomes as biomimetic tools for stem cell differentiation: Applications in dental pulp tissue regeneration.

ABSTRACT: Achieving and maintaining safe and reliable lineage specific differentiation of stem cells is important for clinical translation of tissue engineering strategies. In an effort to circumvent the multitude of problems arising from the usage of growth factors and growth factor delivery systems, we have explored the use of exosomes as biomimetic tools to induce stem cell differentiation. Working on the hypothesis that cell-type specific exosomes can trigger lineage-specific differentiation of stem cells, we have evaluated the potential of exosomes derived from dental pulp cells cultured on under growth and odontogenic differentiation conditions to induce odontogenic differentiation of naïve human dental pulp stem cells (DPSCs) and human bone marrow derived stromal cells (HMSCs) in vitro and in

SUBMITTER: Huang CC 

PROVIDER: S-EPMC5293278 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature