Chronic myeloid leukemia among patients with a history of prior malignancies: A tale of dual survivorship.

ABSTRACT:

Background

Some patients with chronic myeloid leukemia (CML) have a history of previous malignancies. To the authors' knowledge, outcomes for CML diagnosed in these patients have not been well described. The current study was conducted to determine the outcome of patients with CML and a history of prior malignancies.

Methods

The current study included patients who were enrolled in clinical trials of tyrosine kinase inhibitors as initial therapy for CML in chronic phase from July 2000 to January 2014.

Results

Of the 630 patients with CML who were treated with frontline tyrosine kinase inhibitors, 626 had a known prior malignancy status. Of these, 45 patients (7%) had a prior malignancy other than nonmelanoma skin cancer whereas 17 patients (3%) had a history of nonmela

SUBMITTER: Koller PB 

PROVIDER: S-EPMC5293656 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature