A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence.

ABSTRACT: Subjective responses to alcohol are considered candidate endophenotypes for alcohol use disorder and appear to anticipate future consumption. However, prospective studies have been rare, and laboratory research has typically examined subjective responses absent measures of self-administration. This study examined the association of subjective responses with subsequent laboratory self-administration, also evaluating laboratory phenotypes in relation to putative genetic risk factors [family history (FH) of alcohol dependence and OPRM1 genotype] and subsequent heavy drinking. Participants (N = 61, M = 19.89 years, SD = 0.86) completed laboratory sessions involving intravenous alcohol challenge (Session 1) and free-access intravenous self-administration (Session 2), followed by prospective ass

SUBMITTER: Hendershot CS 

PROVIDER: S-EPMC5293674 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature