Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.

ABSTRACT: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.

SUBMITTER: Zhang XD 

PROVIDER: S-EPMC5293734 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature