Development of a Novel Simulation Reactor for Chronic Exposure to Atmospheric Particulate Matter.

ABSTRACT: Epidemiological studies have shown that air pollution is associated with the morbidity and mortality from cardiopulmonary diseases. Currently, limited experimental models are available to evaluate the physiological and cellular pathways activated by chronic multi-pollutant exposures. This manuscript describes an atmospheric simulation reactor (ASR) that was developed to investigate the health effects of air pollutants by permitting controlled chronic in vivo exposure of mice to combined particulate and gaseous pollutants. BALB/c mice were exposed for 1 hr/day for 3 consecutive days to secondary organic aerosol (SOA, a common particulate air pollutant) at 10-150 μg/m³, SOA (30 μg/m³) + ozone (65 ppb) or SOA + ozone (65 ppb) + nitrogen dioxide (NO₂; 100 ppb).

SUBMITTER: Ye J 

PROVIDER: S-EPMC5294446 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature