Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array.

ABSTRACT: Noninvasive measurement of the distribution and oxygenation state of hemoglobin (Hb) inside the tissue is strongly required to analyze the tumor-associated vasculatures. We developed a photoacoustic imaging (PAI) system with a hemispherical-shaped detector array (HDA). Here, we show that PAI system with HDA revealed finer vasculature, more detailed blood-vessel branching structures, and more detailed morphological vessel characteristics compared with MRI by the use of breast shape deformation of MRI to PAI and their fused image. Morphologically abnormal peritumoral blood vessel features, including centripetal photoacoustic signals and disruption or narrowing of vessel signals, were observed and intratumoral signals were detected by PAI in breast cancer tissues as a result of the clinical s

SUBMITTER: Toi M 

PROVIDER: S-EPMC5294462 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature