Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study.

ABSTRACT:

Background

Previous studies suggested a relationship between aspirin use and mortality reduction. The mechanism for the effect of aspirin on cancer outcomes remains unclear. The aim of this study was to evaluate aspirin use and survival in patients with gastrointestinal tract cancer.

Methods

Patients with gastrointestinal tract cancer diagnosed between 1998 and 2011 were included. The population-based Eindhoven Cancer Registry was linked to drug-dispensing data from the PHARMO Database Network. The association between aspirin use after diagnosis and overall survival was analysed using Cox regression models.

Results

In total, 13 715 patients were diagnosed with gastrointestinal cancer. A total of 1008 patients were identified as aspirin users, and 8278 patients were id

SUBMITTER: Frouws MA 

PROVIDER: S-EPMC5294482 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature