The WE-Study: does botulinum toxin A make walking easier in children with cerebral palsy?: Study protocol for a randomized controlled trial.

ABSTRACT:

Background

Intramuscular injections of botulinum toxin A (BoNT-A) have been a cornerstone in the treatment of spasticity for the last 20 years. In Norway, the treatment is now offered to two out of three children with spastic cerebral palsy (CP). However, despite its common use, the evidence for its functional effects is limited and inconclusive. The objective of this study is to determine whether BoNT-A makes walking easier in children with CP. We hypothesize that injections with BoNT-A in the calf muscles will reduce energy cost during walking, improve walking capacity, increase habitual physical activity, reduce pain and improve self-perceived performance and satisfaction.

Methods/design

This randomized, double-blinded, placebo-controlled, multicenter trial is conducted i

SUBMITTER: Brændvik SM 

PROVIDER: S-EPMC5294730 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature