Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis.

ABSTRACT: In meiotic prophase I, homologous chromosome pairing is promoted through chromosome movement mediated by nuclear envelope proteins, microtubules, and dynein. After proper homologue pairing has been established, the synaptonemal complex (SC) assembles along the paired homologues, stabilizing their interaction and allowing for crossing over to occur. Previous studies have shown that perturbing chromosome movement leads to pairing defects and SC polycomplex formation. We show that FKB-6 plays a role in SC assembly and is required for timely pairing and proper double-strand break repair kinetics. FKB-6 localizes outside the nucleus, and in its absence, the microtubule network is altered. FKB-6 is required for proper movement of dynein, increasing resting time between movements. Attenuating chr

SUBMITTER: Alleva B 

PROVIDER: S-EPMC5294783 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature