Control of Initiation of DNA Replication in Bacillus subtilis and Escherichia coli.

ABSTRACT: Initiation of DNA Replication is tightly regulated in all cells since imbalances in chromosomal copy number are deleterious and often lethal. In bacteria such as Bacillus subtilis and Escherichia coli, at the point of cytokinesis, there must be two complete copies of the chromosome to partition into the daughter cells following division at mid-cell during vegetative growth. Under conditions of rapid growth, when the time taken to replicate the chromosome exceeds the doubling time of the cells, there will be multiple initiations per cell cycle and daughter cells will inherit chromosomes that are already undergoing replication. In contrast, cells entering the sporulation pathway in B. subtilis can do so only during a short interval in the cell cycle when there are two, and only two, chromoso

SUBMITTER: Jameson KH 

PROVIDER: S-EPMC5295017 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature