Folate and Vitamin B12-Related Biomarkers in Relation to Brain Volumes.

ABSTRACT: We investigated cross-sectional associations between circulating homocysteine, folate, biomarkers of vitamin B12 status and brain volumes. We furthermore compared brain volumes of participants who received daily folic acid and vitamin B12 supplementation with participants who did not. Participants of the B-PROOF study (n = 2919) were assigned to 400 µg folic acid and 500 µg vitamin B12, or a placebo. After two years of intervention, T₁-weighted magnetic resonance imaging (MRI) scans were made in a random subsample (n = 218) to obtain grey and white matter volume, and total brain volume (TBV). Plasma homocysteine, serum folate, vitamin B12, holotranscobalamin, and methylmalonic acid concentrations were measured. Multiple linear regression analyses showed inverse associations between plasma

SUBMITTER: van der Zwaluw NL 

PROVIDER: S-EPMC5295052 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature