Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men.

ABSTRACT: African American men have higher incidence rates of aggressive prostate cancer, where high levels of calcium and serum vitamin D deficient levels play a role in the racial differences in incidence. In this study, we examined associations of serum vitamin D with aggressive prostate cancer to improve our understanding of higher susceptibility of aggressive disease in this racial cohort. From Howard University Hospital, 155 African American men with clinically-identified prostate cancer were identified; 46 aggressive cases, and 58 non-aggressive cases. Serum vitamin D was assessed from fasting blood samples, and total calcium intake was assessed using the Block Food Frequency Questionnaire. Vitamin D receptor polymorphisms from three different loci were genotyped; rs731236, rs1544410, and rs1

SUBMITTER: Nelson SM 

PROVIDER: S-EPMC5295056 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature