Prognostic value of long non-coding RNA UCA1 in human solid tumors.

ABSTRACT:

Background

Numerous studies have shown that the expression of UCA1 was aberrantly upregulated in various cancer types. High expression of UCA1 was reported to be associated with unfavorable prognosis in cancer patients.

Results

A total of 1240 patients from 15 articles were included. The results indicated that a significantly shorter OS was observed in patients with high expression level of UCA1 (HR = 1.71, 95% CI: 1.43-1.99), in the subgroup analysis, the association was also observed in patients with cancers of digestive system (HR = 2.12, 95% CI: 1.59-2.66). Statistical significance was also observed in subgroup meta-analysis stratified by the cancer type, cut-off value, analysis type and sample size. Furthermore, poorer DFS was observed in patients with high expression l

SUBMITTER: Liu FT 

PROVIDER: S-EPMC5295406 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature