Advanced new strategies for metastatic cancer treatment by therapeutic stem cells and oncolytic virotherapy.

ABSTRACT: The field of therapeutic stem cell and oncolytic virotherapy for cancer treatment has rapidly expanded over the past decade. Oncolytic viruses constitute a promising new class of anticancer agent because of their ability to selectively infect and destroy tumor cells. Engineering of viruses to express anticancer genes and specific cancer targeting molecules has led to the use of these systems as a novel platform of metastatic cancer therapy. In addition, stem cells have a cancer specific migratory capacity, which is available for metastatic cancer targeting. Prodrug activating enzyme or anticancer cytokine expressing stem cells successfully inhibited the proliferation of cancer cells. Preclinical models have clearly demonstrated anticancer activity of these two platforms against a number of

SUBMITTER: Park GT 

PROVIDER: S-EPMC5295462 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature