Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade.

ABSTRACT: Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality worldwide, with myocardial infarction as the most common etiology. HF is characterized by β-adrenergic receptor (βAR) dysregulation that is primarily due to the upregulation of G protein-coupled receptor kinases that leads to overdesensitization of β1 and β2ARs, and this clinically manifests as a loss of inotropic reserve. Interestingly, the "minor" βAR isoform, the β3AR, found in the heart, lacks G protein-coupled receptor kinases recognition sites, and is not subject to desensitization, and as a consequence of this, in human failing myocardium, the levels of this receptor remain unchanged or are even increased. In different preclinical studies, it has been shown that β3ARs can activate different sig

SUBMITTER: Cannavo A 

PROVIDER: S-EPMC5295490 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature