Genomics of Compensatory Adaptation in Experimental Populations of Aspergillus nidulans.

ABSTRACT: Knowledge of the number and nature of genetic changes responsible for adaptation is essential for understanding and predicting evolutionary trajectories. Here, we study the genomic basis of compensatory adaptation to the fitness cost of fungicide resistance in experimentally evolved strains of the filamentous fungus Aspergillus nidulans The original selection experiment tracked the fitness recovery of lines founded by an ancestral strain that was resistant to fludioxonil, but paid a fitness cost in the absence of the fungicide. We obtained whole-genome sequence data for the ancestral A. nidulans strain and eight experimentally evolved strains. We find that fludioxonil resistance in the ancestor was likely conferred by a mutation in histidine kinase nikA, part of the tw

SUBMITTER: Dettman JR 

PROVIDER: S-EPMC5295591 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature