AR-Signaling in Human Malignancies: Prostate Cancer and Beyond.

ABSTRACT: In the 1940s Charles Huggins reported remarkable palliative benefits following surgical castration in men with advanced prostate cancer, and since then the androgen receptor (AR) has remained the main therapeutic target in this disease. Over the past couple of decades, our understanding of AR-signaling biology has dramatically improved, and it has become apparent that the AR can modulate a number of other well-described oncogenic signaling pathways. Not surprisingly, mounting preclinical and epidemiologic data now supports a role for AR-signaling in promoting the growth and progression of several cancers other than prostate, and early phase clinical trials have documented preliminary signs of efficacy when AR-signaling inhibitors are used in several of these malignancies. In this article,

SUBMITTER: Schweizer MT 

PROVIDER: S-EPMC5295778 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature