Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy.

ABSTRACT: Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease. However, a significant number of patients acquire treatment resistance leading to castration resistant prostate cancer (CRPC). Epigenetics, the study of heritable and reversible changes in gene expression without alterations in DNA sequences, is a crucial regulatory step in AR signaling. We and others, recently described the technological advance Chem-seq, a method to identify the interaction between a drug and the genome. This has permitted better understanding of the underlying regulatory mechanisms of AR during carcinogenesis and revealed the importance of epigenetic modifiers. In screeni

SUBMITTER: Cucchiara V 

PROVIDER: S-EPMC5295780 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature