TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis.

ABSTRACT: Foxp3⁺ T regulatory cells (Tregs), conventional CD4⁺Foxp3^- T cells, and CD8⁺ T cells represent heterogeneous populations composed of naive phenotype (NP, CD44^low) and memory phenotype (MP, CD44^high) subpopulations. NP and MP subsets differ in their activation state, contribution to immune function, and capacity to proliferate in vivo. To further understand the factors that contribute to the differential homeostasis of NP/MP subsets, we examined the differential effects of CD28 and CTLA-4 interaction with CD80/CD86, as well as MHC class II-TCR interaction within mouse Treg pools and CD4⁺ and CD8⁺ T cell pools. Blockade of CD80/CD86 with CTLA-4-Ig markedly reduced the cycling and absolute numbers of MP Tr

SUBMITTER: Holt MP 

PROVIDER: S-EPMC5296272 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature