Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.

ABSTRACT:

Background/objectives

Central adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders independently of body mass index (BMI) and are gaining clinically utility. Several studies report genetic variants associated with central adiposity, but most utilize only European ancestry populations. Understanding whether the genetic associations discovered among mainly European descendants are shared with African ancestry populations will help elucidate the biological underpinnings of abdominal fat deposition.

Subjects/methods

To identify the underlying functional genetic determinants of body fat distribution, we conducted an array-wide association meta-analysis among persons of African ancestry across seven studies/

SUBMITTER: Yoneyama S 

PROVIDER: S-EPMC5296276 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature