Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection.

ABSTRACT: Regulatory T (T_reg) cells establish tolerance, prevent inflammation at mucosal surfaces, and regulate immunopathology during infectious responses. Recent studies have shown that Delta-like ligand 4 (Dll4) was upregulated on APC after respiratory syncytial virus (RSV) infection, and its inhibition leads to exaggerated immunopathology. In the present study, we outline the role of Dll4 in T_reg cell differentiation, stability, and function in RSV infection. We found that Dll4 was expressed on CD11b⁺ pulmonary dendritic cells in the lung and draining lymph nodes in wild-type BALB/c mice after RSV infection. Dll4 neutralization exacerbated RSV-induced disease pathology, mucus production, group 2 innate lymphoid cell infiltration, IL-5 and IL-13 production, as wel

SUBMITTER: Ting HA 

PROVIDER: S-EPMC5296281 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature