Increased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition.

ABSTRACT: Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow to cardiac defects remain unclear. Endothelial-mesenchymal cell transition is one of the many complex developmental events involved in transforming the early embryonic outflow tract into the aorta, pulmonary trunk, interventricular septum, and semilunar valves. This study elucidated the effects of increased hemodynamic load on endothelial-mesenchymal transition remodeling of the outflow tract cushions in vivo. Outflow tract banding was used to increase hemodynamic load in the chicken emb

SUBMITTER: Midgett M 

PROVIDER: S-EPMC5296359 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature