Differential Patterns of Risk Factors for Early-Onset Breast Cancer by ER Status in African American Women.

ABSTRACT:

Background

Given the disproportionately high incidence of early-onset breast cancer and aggressive subtypes, such as estrogen receptor (ER)-negative tumors, in African American (AA) women, elucidation of risk factors for early onset of specific subtypes of breast cancer is needed.

Methods

We evaluated associations of reproductive, anthropometric, and other factors with incidence of invasive breast cancer by age at onset (<45, ≥45) in 57,708 AA women in the prospective Black Women's Health Study. From 1995 to 2013, we identified 529 invasive breast cancers among women <45 years of age (151 ER^-, 219 ER⁺) and 1,534 among women ≥45 years (385 ER^-, 804 ER⁺). We used multivariable Cox proportional hazards regression to estimate hazard ra

SUBMITTER: Bertrand KA 

PROVIDER: S-EPMC5296374 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature