BCL6 mRNA Expression Level in Invasive Duct Carcinoma not otherwise Specified.

ABSTRACT:

Introduction

B-Cell Lymphoma 6 (BCL6) has an oncogenic role in tumourigenesis of various malignancies. It represses genes involved in terminal differentiation and plays complementary role with Signal Transducer and Activator of Transcription 3 (STAT3) in triple-negative breast cancer cellular function.

Aim

To evaluate the expression of BCL6 in cancer breast and determine its correlation with the clinico-pathological features including the molecular subtype of breast carcinoma.

Materials and methods

This prospective case control study was carried out on 150 patients, divided into 100 cases of invasive duct carcinoma not otherwise specified and 50 benign breast lesions including fibroadenoma and fibrocystic disease. Fresh tissues were excised, which were then subjected

SUBMITTER: Badr E 

PROVIDER: S-EPMC5296560 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature