DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

ABSTRACT: The DNA damage response (DDR) orchestrates a network of cellular processes that integrates cell-cycle control and DNA repair or apoptosis, which serves to maintain genome stability. DNA-PKcs (the catalytic subunit of the DNA-dependent kinase, encoded by PRKDC), ATM (ataxia telangiectasia, mutated), and ATR (ATM and Rad3-related) are related PI3K-like protein kinases and central regulators of the DDR. Defects in these kinases have been linked to neurodegenerative or neurodevelopmental syndromes. In all cases, the key neuroprotective function of these kinases is uncertain. It also remains unclear how interactions between the three DNA damage-responsive kinases coordinate genome stability, particularly in a physiological context. Here, we used a genetic approach to identify the neural functio

SUBMITTER: Enriquez-Rios V 

PROVIDER: S-EPMC5296783 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature