Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.

ABSTRACT:

Background

Osteoarthritis (OA) is a chronic debilitating joint disorder of particularly high prevalence in the elderly population. Intra-articular basic calcium phosphate (BCP) crystals are present in the majority of OA joints and are associated with severe degeneration. They are known to activate macrophages, synovial fibroblasts, and articular chondrocytes, resulting in increased cell proliferation and the production of pro-inflammatory cytokines and matrix metalloproteases (MMPs). This suggests a pathogenic role in OA by causing extracellular matrix degradation and subchondral bone remodelling. There are currently no disease-modifying drugs available for crystal-associated OA; hence, the aim of this study was to explore the inflammatory pathways activated by BCP crystals in orde

SUBMITTER: Corr EM 

PROVIDER: S-EPMC5296949 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature