Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection.

ABSTRACT:

Background

The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the common terminal reaction in the gluconeogenic/glycogenolytic pathways and plays a central role in glucose homeostasis. In most mammals, different G6PC subunits are encoded by three paralogous genes (G6PC, G6PC2, and G6PC3). Mutations in G6PC and G6PC3 are responsible for human mendelian diseases, whereas variants in G6PC2 are associated with fasting glucose (FG) levels.

Results

We analyzed the evolutionary history of G6Pase genes. Results indicated that the three paralogs originated during early vertebrate evolution and that negative selection was the major force shaping diversity at these genes in mammals. Nonetheless, site-wise estimation of evolutionary rates at corresponding sites revealed we

SUBMITTER: Al-Daghri NM 

PROVIDER: S-EPMC5297017 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature