Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates.

ABSTRACT: Isoprenoid-substituted bisphosphonates are known to serve as inhibitors of the enzyme geranylgeranyl diphosphate synthase, and their activity can be highly sensitive to olefin stereochemistry. A mixture of homogeranyl and homoneryl triazole bisphosphonates has previously demonstrated potent activity, and thus stereocontrolled syntheses of the individual isomers have been developed.

SUBMITTER: Matthiesen RA 

PROVIDER: S-EPMC5297151 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature