Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.

ABSTRACT: Chronic viral infections are characterized by a state of CD8⁺ T-cell dysfunction that is associated with expression of the programmed cell death 1 (PD-1) inhibitory receptor. A better understanding of the mechanisms that regulate CD8⁺ T-cell responses during chronic infection is required to improve immunotherapies that restore function in exhausted CD8⁺ T cells. Here we identify a population of virus-specific CD8⁺ T cells that proliferate after blockade of the PD-1 inhibitory pathway in mice chronically infected with lymphocytic choriomeningitis virus (LCMV). These LCMV-specific CD8⁺ T cells expressed the PD-1 inhibitory receptor, but also expressed several costimulatory molecules such as ICOS and CD28. This CD8⁺ T-cell subs

SUBMITTER: Im SJ 

PROVIDER: S-EPMC5297183 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature