Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study.

ABSTRACT:

Background

DNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol in 725 participants of the Rotterdam Study, a population-based cohort study. Subsequently, we sought replication in a non-overlapping set of 760 participants.

Results

Genome-wide methylation levels were measured in whole blood using the Illumina Methylation 450 array. Associations between lipid levels and DNA methylation beta values were examined using linear mixed-effect models. All models were adjusted for sex, age, smoking, white bloo

SUBMITTER: Braun KVE 

PROVIDER: S-EPMC5297218 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature