Approaches to Investigating Complex Genetic Traits in a Large-Scale Inbred Mouse Aging Study.

ABSTRACT: Inbred mice are a unique model system for studying aging because of the genetic homogeneity within inbred strains, the short life span of mice relative to humans, and the rich array of analytic tools that are available. A large-scale aging study was conducted on 28 inbred strains representing great genetic diversity to determine, via histopathology, the type and diversity of spontaneous diseases that aging mice develop. A total of 20 885 different diagnoses were made, with an average of 12 diagnoses per mouse in the study. Eighteen inbred strains have had their genomes sequenced, and many others have been partially sequenced to provide large repositories of data on genetic variation among the strains. This vast amount of genomic information can be utilized in genome-wide association studie

SUBMITTER: Sundberg JP 

PROVIDER: S-EPMC5297262 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature