Processing speed impairment in schizophrenia is mediated by white matter integrity.

ABSTRACT:

Background

Processing speed predicts functional outcome and is a potential endophenotype for schizophrenia. Establishing the neural basis of processing speed impairment may inform the treatment and etiology of schizophrenia. Neuroimaging investigations in healthy subjects have linked processing speed to brain anatomical connectivity. However, the relationship between processing speed impairment and white matter (WM) integrity in schizophrenia is unclear.

Method

Individuals with schizophrenia and healthy subjects underwent diffusion tensor imaging (DTI) and completed a brief neuropsychological assessment that included measures of processing speed, verbal learning, working memory and executive functioning. Group differences in WM integrity, inferred from fractional anisotropy

SUBMITTER: Karbasforoushan H 

PROVIDER: S-EPMC5297385 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature