Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies.

ABSTRACT: With the development of molecular cloning technology and the deep understanding of antibody engineering, there are diverse bispecific antibody formats from which to choose to pursue the optimal biological activity and clinical purpose. The single-chain-based bispecific antibodies usually bridge tumor cells with immune cells and form an immunological synapse because of their relatively small size. Bispecific antibodies in the IgG format include asymmetric bispecific antibodies and homodimerized bispecific antibodies, all of which have an extended blood half-life and their own crystalline fragment (Fc)-mediated functions. Besides retargeting effector cells to the site of cancer, new applications were established for bispecific antibodies. Bispecific antibodies that can simultaneously bind to

SUBMITTER: Yang F 

PROVIDER: S-EPMC5297683 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature