Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of Statins.

ABSTRACT: In the era of precision medicine, more attention is paid to the search for predictive markers of treatment efficacy and tolerability. Statins are one of the classes of drugs that could benefit from this approach because of their wide use and their incidence of adverse events. Literature from PubMed databases and bibliography from retrieved publications have been analyzed according to terms such as statins, pharmacogenetics, epigenetics, toxicity and drug-drug interaction, among others. The search was performed until 1 October 2016 for articles published in English language. Several technical and methodological approaches have been adopted, including candidate gene and next generation sequencing (NGS) analyses, the latter being more robust and reliable. Among genes identified as possible pr

SUBMITTER: Arrigoni E 

PROVIDER: S-EPMC5297738 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature