A comprehensive family-based replication study of schizophrenia genes.

ABSTRACT:

Importance

Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the specific genetic variants and pathways that increase susceptibility to SCZ is critical to improve disease understanding and address the urgent need for new drug targets.

Objective

To identify SCZ susceptibility genes.

Design

We integrated results from a meta-analysis of 18 genome-wide association studies (GWAS) involving 1,085,772 single-nucleotide polymorphisms (SNPs) and 6 databases that showed significant informativeness for SCZ. The 9380 most promising SNPs were then specifically genotyped in an independent family-based replication study that, after quality control, consisted of 8107 SNPs.

Setting

Linkage meta-analysis, brain transcriptome meta-analysis, candidate gene da

SUBMITTER: Aberg KA 

PROVIDER: S-EPMC5297889 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature