Strategies for carbohydrate model building, refinement and validation.

ABSTRACT: Sugars are the most stereochemically intricate family of biomolecules and present substantial challenges to anyone trying to understand their nomenclature, reactions or branched structures. Current crystallographic programs provide an abstraction layer allowing inexpert structural biologists to build complete protein or nucleic acid model components automatically either from scratch or with little manual intervention. This is, however, still not generally true for sugars. The need for carbohydrate-specific building and validation tools has been highlighted a number of times in the past, concomitantly with the introduction of a new generation of experimental methods that have been ramping up the production of protein-sugar complexes and glycoproteins for the past decade. While some incipien

SUBMITTER: Agirre J 

PROVIDER: S-EPMC5297920 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature