Glycoblocks: a schematic three-dimensional representation for glycans and their interactions.

ABSTRACT: The close-range interactions provided by covalently linked glycans are essential for the correct folding of glycoproteins and also play a pivotal role in recognition processes. Being able to visualise protein-glycan and glycan-glycan contacts in a clear way is thus of great importance for the understanding of these biological processes. In structural terms, glycosylation sugars glue the protein together via hydrogen bonds, whereas non-covalently bound glycans frequently harness additional stacking interactions. Finding an unobscured molecular view of these multipartite scenarios is usually far from trivial; in addition to the need to show the interacting protein residues, glycans may contain many branched sugars, each composed of more than ten non-H atoms and offering more than three poten

SUBMITTER: McNicholas S 

PROVIDER: S-EPMC5297921 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature