The Salivary Microbiome and Oral Cancer Risk: a Pilot Study in Fanconi Anemia.

ABSTRACT: Fanconi anemia (FA) is a rare genetic disease characterized by chromosomal instability and impaired DNA damage repair. FA patients develop oral squamous cell carcinoma (OSCC) earlier and more frequently than the general population, especially after hematopoietic stem cell transplantation (HSCT). Although evidence of an etiological role of the local microbiome and carcinogenesis has been mounting, no information exists regarding the oral microbiome of FA patients. The aim of this study was to explore the salivary microbiome of 61 FA patients regarding their oral health status and OSCC risk factors. After answering a questionnaire and receiving clinical examination, saliva samples were collected and analyzed using 16S rRNA sequencing of the V3-V4 hypervariable region. The microbial profiles

SUBMITTER: Furquim CP 

PROVIDER: S-EPMC5298391 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature