Cadmium body burden and increased blood pressure in middle-aged American Indians: the Strong Heart Study.

ABSTRACT: Cadmium (Cd) is an environmental pollutant that has been associated with cardiovascular disease in populations, but the relationship of Cd with hypertension has been inconsistent. We studied the association between urinary Cd concentrations, a measure of total body burden, and blood pressure in American Indians, a US population with above national average Cd burden. Urinary Cd was measured using inductively coupled plasma mass spectrometry, and adjusted for urinary creatinine concentration. Among 3714 middle-aged American Indian participants of the Strong Heart Study (mean age 56 years, 41% male, 67% ever-smokers, 23% taking antihypertensive medications), urinary Cd ranged from 0.01 to 78.48 μg g^-1 creatinine (geometric mean=0.94 μg g^-1) and it was correlated with smo

SUBMITTER: Franceschini N 

PROVIDER: S-EPMC5299034 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature