The canonical semantic network supports residual language function in chronic post-stroke aphasia.

ABSTRACT: Current theories of language recovery after stroke are limited by a reliance on small studies. Here, we aimed to test predictions of current theory and resolve inconsistencies regarding right hemispheric contributions to long-term recovery. We first defined the canonical semantic network in 43 healthy controls. Then, in a group of 43 patients with chronic post-stroke aphasia, we tested whether activity in this network predicted performance on measures of semantic comprehension, naming, and fluency while controlling for lesion volume effects. Canonical network activation accounted for 22%-33% of the variance in language test scores. Whole-brain analyses corroborated these findings, and revealed a core set of regions showing positive relationships to all language measures. We next evaluated

SUBMITTER: Griffis JC 

PROVIDER: S-EPMC5299060 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature