Association between VEGF polymorphisms (-460 T/C and +936 C/T) and retinopathy of prematurity risk: A meta-analysis.

ABSTRACT:

Purpose

Vascular endothelial growth factor (VEGF) contributes to the development of retinopathy of prematurity (ROP). A number of studies investigated the association of ROP with VEGF -460 T/C and +936 C/T polymorphisms but the results were conflicting. In order to derive a more precise estimation of the associations, we performed a meta-analysis of the relationship between VEGF -460 T/C and +936 C/T polymorphisms with ROP in all published studies.

Methods

A literature search was performed systematically using electronic databases. Published literature from PubMed and other databases was retrieved. The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect. Each -460 T/C and +936 C/T polymorphism included four case-control studies including

SUBMITTER: Shukla S 

PROVIDER: S-EPMC5299107 | biostudies-literature | 2016 Jul-Sep

REPOSITORIES: biostudies-literature