Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis.

ABSTRACT: Multiple sclerosis (MS)-induced neuropathic pain deteriorates quality of life in patients but is often refractory to treatment. In experimental autoimmune encephalomyelitis (EAE), a rodent model of MS, animals develop neuropathy and inflammation-induced tissue acidosis, which suggests the involvement of acid-sensing ion channels (ASICs). Also, peripheral neuropathy is reported in MS patients. However, the involvement of the peripheral nervous system (PNS) in MS neuropathic pain remains elusive. This study investigated the contribution of ASICs and peripheral neuropathy in MS-induced neuropathic pain. Elicited pain levels were as high in Asic1a^-/-, Asic2^-/- and Asic3^-/- mice as wild-type mice even though only Asic1a^-/- mice showed reduced EAE dise

SUBMITTER: Wang IC 

PROVIDER: S-EPMC5299449 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature