Platelet-borne complement proteins and their role in platelet-bacteria interactions.

ABSTRACT: Essentials Platelets play an important role in pathogen recognition. Platelets contain several complement factors and can interact with E. coli. Platelet's complement protein C3 differs from plasmatic C3 in its electrophoretic mobility. Upon contact with bacteria, platelets are activated and can enhance complement activation.

Summary

Background The role of platelets in immune defense is increasingly being recognized. Platelets bind complement proteins from plasma, initiate complement activation, and interact with bacteria. However, the contribution of platelets to complement-mediated defense against bacterial infections is not known in detail. Objectives To assess platelet interactions with Escherichia coli strains, and evaluate the contributions of platelet complement proteins to h

SUBMITTER: Arbesu I 

PROVIDER: S-EPMC5299534 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature