Visual Population Receptive Fields in People with Schizophrenia Have Reduced Inhibitory Surrounds.

ABSTRACT: People with schizophrenia (SZ) experience abnormal visual perception on a range of visual tasks, which have been linked to abnormal synaptic transmission and an imbalance between cortical excitation and inhibition. However, differences in the underlying architecture of visual cortex neurons, which might explain these visual anomalies, have yet to be reported in vivo Here, we probed the neural basis of these deficits using fMRI and population receptive field (pRF) mapping to infer properties of visually responsive neurons in people with SZ. We employed a difference-of-Gaussian model to capture the center-surround configuration of the pRF, providing critical information about the spatial scale of the pRFs inhibitory surround. Our analysis reveals that SZ is associated with reduced pRF

SUBMITTER: Anderson EJ 

PROVIDER: S-EPMC5299570 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature