MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons.

ABSTRACT: Collateral branches from axons are key components of functional neural circuits that allow neurons to connect with multiple synaptic targets. Like axon growth and guidance, formation of collateral branches depends on the regulation of microtubules, but how such regulation is coordinated to ensure proper circuit development is not known. Based on microarray analysis, we have identified a role for microtubule-associated protein 7 (MAP7) during collateral branch development of dorsal root ganglion (DRG) sensory neurons. We show that MAP7 is expressed at the onset of collateral branch formation. Perturbation of its expression by overexpression or shRNA knockdown alters axon branching in cultured DRG neurons. Localization and time-lapse imaging analysis reveals that MAP7 is enriched at branch p

SUBMITTER: Tymanskyj SR 

PROVIDER: S-EPMC5299575 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature