Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis.

ABSTRACT:

Background

The evidence on selective serotonin reuptake inhibitors (SSRIs) for major depressive disorder is unclear.

Methods

Our objective was to conduct a systematic review assessing the effects of SSRIs versus placebo, 'active' placebo, or no intervention in adult participants with major depressive disorder. We searched for eligible randomised clinical trials in The Cochrane Library's CENTRAL, PubMed, EMBASE, PsycLIT, PsycINFO, Science Citation Index Expanded, clinical trial registers of Europe and USA, websites of pharmaceutical companies, the U.S. Food and Drug Administration (FDA), and the European Medicines Agency until January 2016. All data were extracted by at least two independent investigators. We used Cochrane systematic review methodology, Trial Sequential Analy

SUBMITTER: Jakobsen JC 

PROVIDER: S-EPMC5299662 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature