Transferability of genome-wide associated loci for asthma in African Americans.

ABSTRACT:

Objective

Transferability of significantly associated loci or GWAS "hits" adds credibility to genotype-disease associations and provides evidence for generalizability across different ancestral populations. We sought evidence of association of known asthma-associated single nucleotide polymorphisms (SNPs) in an African American population.

Methods

Subjects comprised 661 participants (261 asthma cases and 400 controls) from the Howard University Family Study. Forty-eight SNPs previously reported to be associated with asthma by GWAS were selected for testing. We adopted a combined strategy by first adopting an "exact" approach where we looked-up only the reported index SNP. For those index SNPs missing form our dataset, we used a "local" approach that examined all the regional

SUBMITTER: Faruque MU 

PROVIDER: S-EPMC5300042 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature