Heterogeneous Spatial Distribution of Transcriptional Activity in Budding Yeast Nuclei.

ABSTRACT: Recent microscopic and simulation studies have shown that the genome structure fluctuates dynamically in the nuclei of budding yeast Saccharomyces cerevisiae. This genome-wide movement should lead to the fluctuations of individual genes in their territorial regions. This raises an intriguing question of whether the resulting distribution of genes is correlated to their transcriptional activity. An effective method for examining this correlation is to analyze how the spatial distribution of genes and their transcriptional activity are modified by mutation. In this study, we analyzed the modification observed in a budding yeast mutant in which genes necessary for anchoring telomeres to the nuclear envelope, yku70 and esc1, are silenced. Taddei et al. reported that 60 genes are clearly misreg

SUBMITTER: Tokuda N 

PROVIDER: S-EPMC5300786 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature