Genomes of Multicellular Organisms Have Evolved to Attract Nucleosomes to Promoter Regions.

ABSTRACT: Sequences that influence nucleosome positioning in promoter regions, and their relation to gene regulation, have been the topic of much research over the last decade. In yeast, significant nucleosome-depleted regions are found, which facilitate transcription. With the arrival of nucleosome positioning maps for the human genome, it was discovered that in our genome, unlike in that of yeast, promoters encode for high nucleosome occupancy. In this work, we look at the genomes of a range of different organisms, to provide a catalog of nucleosome positioning signals in promoters across the tree of life. We utilize a computational model of the nucleosome, based on crystallographic analyses of the structure and elasticity of the nucleosome, to predict the nucleosome positioning signals in promote

SUBMITTER: Tompitak M 

PROVIDER: S-EPMC5300838 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature