Efficacy of vitamin D₃ supplementation in reducing incidence of pulmonary tuberculosis and mortality among HIV-infected Tanzanian adults initiating antiretroviral therapy: study protocol for a randomized controlled trial.

ABSTRACT:

Background

HIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months of treatment. Observational studies in high-income and resource-limited settings indicate that HIV-infected adults with low vitamin D levels may be at increased risk of mortality, HIV disease progression, and incidence of pulmonary tuberculosis (TB). As a result, vitamin D₃ supplementation may improve survival and treatment outcomes for HIV-infected adults initiating ART.

Methods/design

The Trial of Vitamins-4 (ToV4) is an individually randomized, double-blind, placebo-controlled trial of vitamin D₃ (cholecalciferol) supplementation conducted among 4000 HIV-infected adults wit

SUBMITTER: Sudfeld CR 

PROVIDER: S-EPMC5301352 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature